Quantitative structure-activity relationship modeling on in vitro endocrine effects and metabolic stability involving 26 selected brominated flame retardants.

@article{Harju2007QuantitativeSR,
  title={Quantitative structure-activity relationship modeling on in vitro endocrine effects and metabolic stability involving 26 selected brominated flame retardants.},
  author={Mikael Harju and Timo H M Hamers and Jorke H Kamstra and Edwin Sonneveld and Jan P. Boon and Mats Tysklind and Patrik L. Andersson},
  journal={Environmental toxicology and chemistry},
  year={2007},
  volume={26 4},
  pages={816-26}
}
In this work, quantitative structure-activity relationships (QSARs) were developed to aid human and environmental risk assessment processes for brominated flame retardants (BFRs). Brominated flame retardants, such as the high-production-volume chemicals polybrominated diphenyl ethers (PBDEs), tetrabromobisphenol A, and hexabromocyclododecane, have been identified as potential endocrine disruptors. Quantitative structure-activity relationship models were built based on the in vitro potencies of… CONTINUE READING

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The in vitro assays included interactions with , for example , androgen , progesterone , estrogen , and dioxin ( aryl hydrocarbon ) receptor , plus competition with thyroxine for its plasma carrier protein ( transthyretin ) , inhibition of estradiol sulfation via sulfotransferase , and finally , rate of metabolization .
The in vitro assays included interactions with , for example , androgen , progesterone , estrogen , and dioxin ( aryl hydrocarbon ) receptor , plus competition with thyroxine for its plasma carrier protein ( transthyretin ) , inhibition of estradiol sulfation via sulfotransferase , and finally , rate of metabolization .
The in vitro assays included interactions with , for example , androgen , progesterone , estrogen , and dioxin ( aryl hydrocarbon ) receptor , plus competition with thyroxine for its plasma carrier protein ( transthyretin ) , inhibition of estradiol sulfation via sulfotransferase , and finally , rate of metabolization .
The in vitro assays included interactions with , for example , androgen , progesterone , estrogen , and dioxin ( aryl hydrocarbon ) receptor , plus competition with thyroxine for its plasma carrier protein ( transthyretin ) , inhibition of estradiol sulfation via sulfotransferase , and finally , rate of metabolization .
Experimental properties were included and measured for PBDEs , such as their individual ultraviolet spectra ( 200 - 320 nm ) and retention times on three different high - performance liquid chromatography columns and one nonpolar gas chromatography column .
Experimental properties were included and measured for PBDEs , such as their individual ultraviolet spectra ( 200 - 320 nm ) and retention times on three different high - performance liquid chromatography columns and one nonpolar gas chromatography column .
The in vitro assays included interactions with , for example , androgen , progesterone , estrogen , and dioxin ( aryl hydrocarbon ) receptor , plus competition with thyroxine for its plasma carrier protein ( transthyretin ) , inhibition of estradiol sulfation via sulfotransferase , and finally , rate of metabolization .
The in vitro assays included interactions with , for example , androgen , progesterone , estrogen , and dioxin ( aryl hydrocarbon ) receptor , plus competition with thyroxine for its plasma carrier protein ( transthyretin ) , inhibition of estradiol sulfation via sulfotransferase , and finally , rate of metabolization .
The in vitro assays included interactions with , for example , androgen , progesterone , estrogen , and dioxin ( aryl hydrocarbon ) receptor , plus competition with thyroxine for its plasma carrier protein ( transthyretin ) , inhibition of estradiol sulfation via sulfotransferase , and finally , rate of metabolization .
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The in vitro assays included interactions with , for example , androgen , progesterone , estrogen , and dioxin ( aryl hydrocarbon ) receptor , plus competition with thyroxine for its plasma carrier protein ( transthyretin ) , inhibition of estradiol sulfation via sulfotransferase , and finally , rate of metabolization .
The in vitro assays included interactions with , for example , androgen , progesterone , estrogen , and dioxin ( aryl hydrocarbon ) receptor , plus competition with thyroxine for its plasma carrier protein ( transthyretin ) , inhibition of estradiol sulfation via sulfotransferase , and finally , rate of metabolization .
The in vitro assays included interactions with , for example , androgen , progesterone , estrogen , and dioxin ( aryl hydrocarbon ) receptor , plus competition with thyroxine for its plasma carrier protein ( transthyretin ) , inhibition of estradiol sulfation via sulfotransferase , and finally , rate of metabolization .
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