Quantitative structure-activity relationship studies for prediction of antimicrobial activity of synthesized 2,4-hexadienoic acid derivatives.

@article{Narasimhan2007QuantitativeSR,
  title={Quantitative structure-activity relationship studies for prediction of antimicrobial activity of synthesized 2,4-hexadienoic acid derivatives.},
  author={Balasubramanian Narasimhan and Vikramjeet Judge and Rakesh Narang and Ruchita Ohlan and Sucheta Ohlan},
  journal={Bioorganic & medicinal chemistry letters},
  year={2007},
  volume={17 21},
  pages={5836-45}
}
A new series of 2,4-hexadienoic acid derivatives (S(1)-S(42)) has been synthesized and evaluated as antimicrobial agents against Staphylococcus aureus, Bacillus subtilis, Escherichia coli, Candida albicans, and Aspergillus niger. Quantitative structure-activity relationship (QSAR) investigation using Hansch analysis was applied to find out correlation between antimicrobial activities with physicochemical properties of the synthesized compounds. Various physicochemical descriptors and… CONTINUE READING
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