Quantitative structure--activity relationships. 7. The bilinear model, a new model for nonlinear dependence of biological activity on hydrophobic character.

  • Hugo Kubinyi
  • Published 1977 in Journal of medicinal chemistry

Abstract

The bilinear model, log 1/C =a log P-b log (betaP+1) +C, a new model for nonlinear dependence of biological activity on hydrophobic character, is applied to 57 data sets of biological activity values in homologous series. From a comparison of the statistical parameters and the residuals obtained with the bilinear model and the parabolic model, the… (More)

Cite this paper

@article{Kubinyi1977QuantitativeSR, title={Quantitative structure--activity relationships. 7. The bilinear model, a new model for nonlinear dependence of biological activity on hydrophobic character.}, author={Hugo Kubinyi}, journal={Journal of medicinal chemistry}, year={1977}, volume={20 5}, pages={625-9} }