Quantitative structural changes of the rat thoracic aorta in early spontaneous hypertension. Tissue composition, and hypertrophy and hyperplasia of smooth muscle cells.

@article{Olivetti1982QuantitativeSC,
  title={Quantitative structural changes of the rat thoracic aorta in early spontaneous hypertension. Tissue composition, and hypertrophy and hyperplasia of smooth muscle cells.},
  author={Giorgio Olivetti and M Melissari and Germano Marchetti and Piero Anversa},
  journal={Circulation research},
  year={1982},
  volume={51 1},
  pages={19-26}
}
The thoracic aorta of 21-, 28-, 35-, and 45-day-old spontaneously hypertensive (SH) and Wistar Kyoto (WK) rats was analyzed morphometrically to evaluate the cellular hypertrophy and proliferation of medial smooth muscle cells during the development of genetically determined hypertension. The absolute increase in volume of collagen and ground substance, and elastic tissue was also measured. In SH animals, cellular hypertrophy was found to be the dominant mechanism of muscle growth in the 21- to… CONTINUE READING
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Morphometric study

  • P Anversa, G Olivetti, AV Loud
  • 1980

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