Quantitative spatial distribution of sirolimus and polymers in drug-eluting stents using confocal Raman microscopy.

@article{Balss2008QuantitativeSD,
  title={Quantitative spatial distribution of sirolimus and polymers in drug-eluting stents using confocal Raman microscopy.},
  author={Karin M. Balss and Gerald H. Llanos and George Papandreou and Cynthia A. Maryanoff},
  journal={Journal of biomedical materials research. Part A},
  year={2008},
  volume={85 1},
  pages={
          258-70
        }
}
Raman spectroscopy was used to differentiate each component found in the CYPHER Sirolimus-eluting Coronary Stent. The unique spectral features identified for each component were then used to develop three separate calibration curves to describe the solid phase distribution found on drug-polymer coated stents. The calibration curves were obtained by analyzing confocal Raman spectral depth profiles from a set of 16 unique formulations of drug-polymer coatings sprayed onto stents and planar… CONTINUE READING

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