Quantitative single-cell characterization of bacterial interactions reveals type VI secretion is a double-edged sword.

@article{LeRoux2012QuantitativeSC,
  title={Quantitative single-cell characterization of bacterial interactions reveals type VI secretion is a double-edged sword.},
  author={Michele LeRoux and Justin A. De Leon and Nathan J. Kuwada and Alistair B. Russell and Delia Mar{\'i}a Pinto-Santini and Rachel D. Hood and Danielle M. Agnello and Stephen M Robertson and Paul A. Wiggins and Joseph D Mougous},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2012},
  volume={109 48},
  pages={19804-9}
}
Interbacterial interaction pathways play an important role in defining the structure and complexity of bacterial associations. A quantitative description of such pathways offers promise for understanding the forces that contribute to community composition. We developed time-lapse fluorescence microscopy methods for quantitation of interbacterial interactions and applied these to the characterization of type VI secretion (T6S) in Pseudomonas aeruginosa. Our analyses allowed a direct… CONTINUE READING
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