Quantitative signal detection using spontaneous ADR reporting.

  title={Quantitative signal detection using spontaneous ADR reporting.},
  author={Andrew Bate and Stephen Jw Evans},
  journal={Pharmacoepidemiology and drug safety},
  volume={18 6},
Quantitative methods are increasingly used to analyse spontaneous reports. We describe the core concepts behind the most common methods, the proportional reporting ratio (PRR), reporting odds ratio (ROR), information component (IC) and empirical Bayes geometric mean (EBGM). We discuss the role of Bayesian shrinkage in screening spontaneous reports, the importance of changes over time in screening the properties of the measures. Additionally we discuss three major areas of controversy and… CONTINUE READING
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