Quantitative relationship between the local lymph node assay and human skin sensitization assays.

@article{Schneider2004QuantitativeRB,
  title={Quantitative relationship between the local lymph node assay and human skin sensitization assays.},
  author={Klaus Schneider and Z{\"u}leyha Akkan},
  journal={Regulatory toxicology and pharmacology : RTP},
  year={2004},
  volume={39 3},
  pages={245-55}
}
The local lymph node assay (LLNA) is a new test method which allows for the quantitative assessment of sensitizing potency in the mouse. Here, we investigate the quantitative correlation between results from the LLNA and two human sensitization tests--specifically, human repeat insult patch tests (HRIPTs) and human maximization tests (HMTs). Data for 57 substances were evaluated, of which 46 showed skin sensitizing properties in human tests, whereas 11 yielded negative results in humans. For… CONTINUE READING
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