Quantitative relationship between axonal injury and mechanical response in a rodent head impact acceleration model.

@article{Li2011QuantitativeRB,
  title={Quantitative relationship between axonal injury and mechanical response in a rodent head impact acceleration model.},
  author={Yan Li and Liying Zhang and Srinivasu Kallakuri and Runzhou Zhou and John M. Cavanaugh},
  journal={Journal of neurotrauma},
  year={2011},
  volume={28 9},
  pages={1767-82}
}
A modified Marmarou impact acceleration model was developed to study the mechanical responses induced by this model and their correlation to traumatic axonal injury (TAI). Traumatic brain injury (TBI) was induced in 31 anesthetized male Sprague-Dawley rats (392±13 g) by a custom-made 450-g impactor from heights of 1.25 m or 2.25 m. An accelerometer and angular rate sensor measured the linear and angular responses of the head, while the impact event was captured by a high-speed video camera. TAI… CONTINUE READING
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