Quantitative real-time reverse transcription-polymerase chain reaction analysis of drug metabolizing and cytoprotective genes in psoriasis and regulation by ultraviolet radiation.

@article{Smith2003QuantitativeRR,
  title={Quantitative real-time reverse transcription-polymerase chain reaction analysis of drug metabolizing and cytoprotective genes in psoriasis and regulation by ultraviolet radiation.},
  author={Gill Smith and Robert Dawe and Colin Clark and A. Thomas Evans and Muriel M. Comrie and C. R. Wolf and James Ferguson and Sally Helen Ibbotson},
  journal={The Journal of investigative dermatology},
  year={2003},
  volume={121 2},
  pages={390-8}
}
There are unpredictable inter-individual differences in response to ultraviolet radiation, used in the treatment of psoriasis and other common skin diseases. It is therefore essential that we attempt to identify phenotypic markers that correlate with individual treatment outcomes. Exposure of human skin to ultraviolet radiation results in the generation of reactive intermediates and oxidative stress. Hepatic drug metabolizing and cytoprotective genes are induced as an adaptive response to… CONTINUE READING