Quantitative proteomics reveal up-regulated protein expression of the SET complex associated with hepatocellular carcinoma.

@article{Li2012QuantitativePR,
  title={Quantitative proteomics reveal up-regulated protein expression of the SET complex associated with hepatocellular carcinoma.},
  author={Chen Li and H Ruan and Yan-sheng Liu and Meng-jie Xu and Jie Dai and Q Sheng and Ye-xiong Tan and Zhen-Zhen Yao and Hong-yang Wang and Jia-Rui Wu and Rong Zeng},
  journal={Journal of proteome research},
  year={2012},
  volume={11 2},
  pages={871-85}
}
We combined culture-derived isotope tags (CDITs) with two-dimensional liquid chromatography-tandem mass spectrometry (2D-LC-MS/MS) to extensively survey abnormal protein expression associated with hepatocellular carcinoma (HCC) in clinical tissues. This approach yielded an in-depth quantitated proteome of 1360 proteins. Importantly, 267 proteins were significantly regulated with a fold-change of at least 1.5. The proteins up-regulated in HCC tissues are involved in regulatory processes, such as… CONTINUE READING

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