Quantitative proteomics of fractionated membrane and lumen exosome proteins from isogenic metastatic and nonmetastatic bladder cancer cells reveal differential expression of EMT factors.

@article{Jeppesen2014QuantitativePO,
  title={Quantitative proteomics of fractionated membrane and lumen exosome proteins from isogenic metastatic and nonmetastatic bladder cancer cells reveal differential expression of EMT factors.},
  author={Dennis Kj\olhede Jeppesen and Arkadiusz Nawrocki and Steffen Grann Jensen and Kasper Thorsen and Bradley W. Whitehead and Kenneth A Howard and Lars Dyrskj\ot and Torben F. \Orntoft and Martin R Larsen and Marie Stampe Ostenfeld},
  journal={Proteomics},
  year={2014},
  volume={14 6},
  pages={699-712}
}
Cancer cells secrete soluble factors and various extracellular vesicles, including exosomes, into their tissue microenvironment. The secretion of exosomes is speculated to facilitate local invasion and metastatic spread. Here, we used an in vivo metastasis model of human bladder carcinoma cell line T24 without metastatic capacity and its two isogenic derivate cell lines SLT4 and FL3, which form metastases in the lungs and liver of mice, respectively. Cultivation in CLAD1000 bioreactors rather… CONTINUE READING
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Downregulation of hepatoma-derived growth factor contributes C © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim www.proteomics-journal.com

  • H. E. Tsai, G. S. Liu, M. L. Kung, Liu, F L.
  • Proteomics
  • 2014
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