Quantitative proteomics of cerebrospinal fluid from patients with Alzheimer disease.

  title={Quantitative proteomics of cerebrospinal fluid from patients with Alzheimer disease.},
  author={Jing Zhang and Dave R Goodlett and Joseph F Quinn and E. R. Peskind and Jeffrey A. Kaye and Yong Zhou and Catherine Pan and Eugene Yi and Jimmy Eng and Qin Wang and Ruedi Aebersold and Thomas J. Montine},
  journal={Journal of Alzheimer's disease : JAD},
  volume={7 2},
  pages={125-33; discussion 173-80}
Biomarkers to assist in the diagnosis and medical management of Alzheimer disease (AD) are a pressing need. We have employed a proteomic approach, microcapillary liquid chromatography mass spectrometry of proteins labeled with isotope-coded affinity tags (ICAT), to quantify relative changes in the proteome of human cerebrospinal fluid (CSF) obtained from the lumbar cistern. Using CSF from well-characterized AD patients and age-matched controls at 2 different institutions, we quantified protein… CONTINUE READING


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