Quantitative proteomics of caveolin-1-regulated proteins: characterization of polymerase i and transcript release factor/CAVIN-1 IN endothelial cells.

@article{Dvalos2010QuantitativePO,
  title={Quantitative proteomics of caveolin-1-regulated proteins: characterization of polymerase i and transcript release factor/CAVIN-1 IN endothelial cells.},
  author={Alberto D{\'a}valos and Carlos Fern{\'a}ndez-Hernando and Grzegorz Sowa and Behrad Derakhshan and M. I. Lin and Ji Yoon Lee and Hongyu Zhao and Ruiyan Luo and Christopher M. Colangelo and William C Sessa},
  journal={Molecular & cellular proteomics : MCP},
  year={2010},
  volume={9 10},
  pages={2109-24}
}
Caveolae are organelles abundant in the plasma membrane of many specialized cells including endothelial cells (ECs), epithelial cells, and adipocytes, and in these cells, caveolin-1 (Cav-1) is the major coat protein essential for the formation of caveolae. To identify proteins that require Cav-1 for stable incorporation into membrane raft domains, a quantitative proteomics analysis using isobaric tagging for relative and absolute quantification was performed on rafts isolated from wild-type and… CONTINUE READING