Quantitative proteomics investigation of pancreatic intraepithelial neoplasia.

  title={Quantitative proteomics investigation of pancreatic intraepithelial neoplasia.},
  author={Sheng Pan and Ru Chen and Beth Ann Reimel and David A. Crispin and Hamid Mirzaei and Kelly Cooke and Joshua F Coleman and Zhaoli Lane and Mary P Bronner and David R. Goodlett and Martin W. McIntosh and William L Traverso and Ruedi Aebersold and Teresa A. Brentnall},
  volume={30 7},
Patients with pancreatic cancer are usually diagnosed at late stages, when the disease is incurable. Pancreatic intraepithelial neoplasia (PanIN) 3 is believed to be the immediate precursor lesion of pancreatic adenocarcinoma, and would be an ideal stage to diagnose patients, when intervention and cure are possible and patients are curable. In this study, we used quantitative proteomics to identify dysregulated proteins in PanIN 3 lesions. Altogether, over 200 dysregulated proteins were… CONTINUE READING


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