Quantitative proteomics (2-D DIGE) reveals molecular strategies employed by Burkholderia cenocepacia to adapt to the airways of cystic fibrosis patients under antimicrobial therapy.

@article{Madeira2011QuantitativeP,
  title={Quantitative proteomics (2-D DIGE) reveals molecular strategies employed by Burkholderia cenocepacia to adapt to the airways of cystic fibrosis patients under antimicrobial therapy.},
  author={Andreia Madeira and Pedro Manuel Santos and Carla Patr{\'i}cia Coutinho and Ana Pinto-de-Oliveira and Isabel S{\'a}-Correia},
  journal={Proteomics},
  year={2011},
  volume={11 7},
  pages={1313-28}
}
Chronic respiratory infections caused by Burkholderia cenocepacia in patients with cystic fibrosis (CF) are characterized by low responsiveness to antibiotic therapy and, in general, to a more rapid decline of lung function. To get clues into the molecular mechanisms underlying the adaptive strategies employed to deal with the stressing conditions of the CF lung including antibiotic therapy, quantitative proteomics (2-D DIGE) was used to compare the expression programs of two clonal isolates… CONTINUE READING

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