Quantitative proteomic analysis reveals protein expression changes in the murine neuronal secretome during apoptosis.

@article{Thouvenot2012QuantitativePA,
  title={Quantitative proteomic analysis reveals protein expression changes in the murine neuronal secretome during apoptosis.},
  author={Eric Thouvenot and S. Urbach and Oana Vigy and Martial S{\'e}v{\'e}no and Nathalie Gal{\'e}otti and Genevi{\`e}ve Nguyen and J{\"o}el Bockaert and P. Mar{\'i}n},
  journal={Journal of proteomics},
  year={2012},
  volume={77},
  pages={394-405}
}
Neurodegenerative diseases often lack early and specific diagnostic and prognostic biomarkers. Many studies are focusing on the cerebrospinal fluid (CSF) proteome to identify relevant biomarkers and therapeutic targets for these disorders. An alternative approach consists in comparing proteins secreted by healthy neurons and neurons degenerating by apoptosis, one of the mechanisms underlying neuronal death in neurodegenerative diseases. Here, we adapted the stable isotope labeling by amino… CONTINUE READING

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