Quantitative proteomic analysis reveals a simple strategy of global resource allocation in bacteria

@inproceedings{Hui2015QuantitativePA,
  title={Quantitative proteomic analysis reveals a simple strategy of global resource allocation in bacteria},
  author={Sheng Hui and Josh M Silverman and Stephen S Chen and David W. Erickson and Markus Basan and Jilong Wang and Terence Hwa and James R Williamson},
  booktitle={Molecular systems biology},
  year={2015}
}
A central aim of cell biology was to understand the strategy of gene expression in response to the environment. Here, we study gene expression response to metabolic challenges in exponentially growing Escherichia coli using mass spectrometry. Despite enormous complexity in the details of the underlying regulatory network, we find that the proteome partitions into several coarse-grained sectors, with each sector's total mass abundance exhibiting positive or negative linear relations with the… CONTINUE READING