Quantitative proteomic analysis of the heat stress response in Clostridium difficile strain 630.

@article{Jain2011QuantitativePA,
  title={Quantitative proteomic analysis of the heat stress response in Clostridium difficile strain 630.},
  author={Shailesh Jain and Ciaren Graham and Robert Leslie James Graham and Geoff McMullan and Nigel G Ternan},
  journal={Journal of proteome research},
  year={2011},
  volume={10 9},
  pages={3880-90}
}
Clostridium difficile is a serious nosocomial pathogen whose prevalence worldwide is increasing. Postgenomic technologies can now be deployed to develop understanding of the evolution and diversity of this important human pathogen, yet little is known about the adaptive ability of C. difficile. We used iTRAQ labeling and 2D-LC-MS/MS driven proteomics to investigate the response of C. difficile 630 to a mild, but clinically relevant, heat stress. A statistically validated list of 447 proteins to… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 21 extracted citations

Similar Papers

Loading similar papers…