Quantitative proteomic analysis of mitochondrial proteins: relevance to Lewy body formation and Parkinson's disease.

@article{Jin2005QuantitativePA,
  title={Quantitative proteomic analysis of mitochondrial proteins: relevance to Lewy body formation and Parkinson's disease.},
  author={Jinghua Jin and Gloria E. Meredith and Leo C. Chen and Yong Zhou and Jing Xu and Feng-Shiun Shie and Paul J Lockhart and Jing Zhang},
  journal={Brain research. Molecular brain research},
  year={2005},
  volume={134 1},
  pages={119-38}
}
The mechanisms underlying Parkinson's disease (PD) and Lewy body (LB) formation, a pathological hallmark of PD, are incompletely understood; however, mitochondrial dysfunction is likely to be at least partially responsible. To study the processes that might be related to nigral neurodegeneration and LB formation, we employed nonbiased quantitative proteomics with isotope-coded affinity tag (ICAT) to compare the mitochondrial protein profiles in the substantia nigra (SN) between controls and… CONTINUE READING