Quantitative proteomic analysis of induced pluripotent stem cells derived from a human Huntington's disease patient.

@article{Chae2012QuantitativePA,
  title={Quantitative proteomic analysis of induced pluripotent stem cells derived from a human Huntington's disease patient.},
  author={Jung-Il Chae and Dong-wook Kim and Nayeon Lee and Young-Joo Jeon and Iksoo Jeon and Jihye Kwon and Jumi Kim and Yunjo Soh and Dong-Seok Lee and Kang Seok Seo and N J Choi and Byoung Chul Park and Sung Hyun Kang and Joohyun Ryu and Seung-Hun Oh and Dong Ah Shin and Dong Ryul Lee and Jeong Tae Do and In-Hyun Park and George Q. Daley and Jihwan Song},
  journal={The Biochemical journal},
  year={2012},
  volume={446 3},
  pages={359-71}
}
HD (Huntington's disease) is a devastating neurodegenerative genetic disorder caused by abnormal expansion of CAG repeats in the HTT (huntingtin) gene. We have recently established two iPSC (induced pluripotent stem cell) lines derived from a HD patient carrying 72 CAG repeats (HD-iPSC). In order to understand the proteomic profiles of HD-iPSCs, we have performed comparative proteomic analysis among normal hESCs (human embryonic stem cells; H9), iPSCs (551-8) and HD-iPSCs at undifferentiated… CONTINUE READING
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