Quantitative proteomic analysis of phosphotyrosine-mediated cellular signaling networks.

@article{Zhang2007QuantitativePA,
  title={Quantitative proteomic analysis of phosphotyrosine-mediated cellular signaling networks.},
  author={Yi Irvette Zhang and Alejandro Wolf-Yadlin and Forest M. White},
  journal={Methods in molecular biology},
  year={2007},
  volume={359},
  pages={
          203-12
        }
}
Receptor tyrosine kinases receive extracellular cues, such as ligand binding, and transmit this information to the cell through both autophosphorylation and phosphorylation of tyrosine residues on selected substrates, stimulating a variety of signal transduction pathways. Quantitative features, including intensity, timing, and duration of phosphorylation of particular residues, may play a role in determining cellular response, but experimental data required for analysis of these features have… CONTINUE READING
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