Quantitative proteomic analysis identified paraoxonase 1 as a novel serum biomarker for microvascular invasion in hepatocellular carcinoma.

@article{Huang2013QuantitativePA,
  title={Quantitative proteomic analysis identified paraoxonase 1 as a novel serum biomarker for microvascular invasion in hepatocellular carcinoma.},
  author={Chen Huang and Yuwei Wang and Shengdong Liu and Guangyu Ding and Weiren Liu and Jian Zhou and Ming Kuang and Yuan Ji and Tadashi Kondo and Jia Fan},
  journal={Journal of proteome research},
  year={2013},
  volume={12 4},
  pages={1838-46}
}
This study aimed to identify serum biomarkers for microvascular invasion (MVI) in hepatocellular carcinoma (HCC). MVI is a histological sign of micrometastasis in the liver and is considered as one of the most powerful prognostic factors in HCC. The serum of HCC patients with different vascular invasion statuses was examined by iTRAQ-based proteomic profiling. The expression levels of 24 proteins were associated with the extent of vascular invasion in the pooled samples of 45 HCC cases. Western… CONTINUE READING

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Western blot analyses in 90 HCC cases confirmed the correlation of the expression level of paraoxonase 1 ( PON1 ) with the extent of vascular invasion .
Western blot analyses in 90 HCC cases confirmed the correlation of the expression level of paraoxonase 1 ( PON1 ) with the extent of vascular invasion .
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