Quantitative promoter methylation analysis of hepatocellular carcinoma, cirrhotic and normal liver.

@article{Harder2008QuantitativePM,
  title={Quantitative promoter methylation analysis of hepatocellular carcinoma, cirrhotic and normal liver.},
  author={Jan Harder and Oliver G. Opitz and Jan Brabender and M. Olschewski and H. E. Blum and Shuji Nomoto and Henning Usadel},
  journal={International journal of cancer},
  year={2008},
  volume={122 12},
  pages={2800-4}
}
Hepatocellular carcinoma (HCC) is one of the most common cancers worldwide. Little is known about its molecular pathogenesis and the relevance of DNA methylation for disease initiation and progression. Nevertheless, promoter methylation of some genes has been implicated as potential marker for HCC. Thirty-four HCC, 34 matching non-malignant, cirrhotic livers and 16 normal livers were analyzed for the methylation status of the genes p16(INK4a), GSTP1, MGMT, DAP-K and APC by quantitative… CONTINUE READING

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