Quantitative promoter hypermethylation profiles of ductal carcinoma in situ in North American and Korean women: Potential applications for diagnosis.

@article{Lee2008QuantitativePH,
  title={Quantitative promoter hypermethylation profiles of ductal carcinoma in situ in North American and Korean women: Potential applications for diagnosis.},
  author={Ji Shin Lee and Mary Jo Fackler and Wei Wen Teo and Jae Hyuk Lee and Chan Choi and Min Ho Park and Jung Han Yoon and Zhe Zhang and Pedram Argani and Saraswati V. Sukumar},
  journal={Cancer biology & therapy},
  year={2008},
  volume={7 9},
  pages={1398-406}
}
To investigate the diagnostic potential of DNA methylation-based markers in tissue samples of DCIS, we examined the prevalence and extent of methylation in breast ductal carcinoma in situ (DCIS) samples from North American and Korean women. Quantitative multiplex-methylation specific PCR (QM-MSP) of ten genes was performed. The methylation level of APC1, Cyclin D2, HIN-1, RASSF1A and Twist singly, and cumulative methylation of all ten genes was significantly higher in DCIS compared to normal… CONTINUE READING
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