Quantitative prediction of the extent of drug-drug interaction using a physiologically based pharmacokinetic model that includes inhibition of drug metabolism determined in cryopreserved hepatocytes.

Abstract

1. A physiologically based pharmacokinetic (PBPK) model that includes inhibition constant evaluated in cryopreserved hepatocytes was used to predict drug-drug interactions (DDIs) between orally administered nifedipine, a CYP substrate, and fluconazole or ketoconazole, CYP inhibitors, in rats. 2. The Kp,uu, ratio of unbound inhibitor concentration in liver… (More)
DOI: 10.1080/00498254.2017.1370744

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@article{Iwasaki2017QuantitativePO, title={Quantitative prediction of the extent of drug-drug interaction using a physiologically based pharmacokinetic model that includes inhibition of drug metabolism determined in cryopreserved hepatocytes.}, author={Shinji Iwasaki and Hideki Hirabayashi and Nobuyuki Amano}, journal={Xenobiotica; the fate of foreign compounds in biological systems}, year={2017}, pages={1-11} }