Quantitative polymerase chain reaction for the detection of micrometastases in patients with breast cancer.

@article{Slade1999QuantitativePC,
  title={Quantitative polymerase chain reaction for the detection of micrometastases in patients with breast cancer.},
  author={Martin J. Slade and Brendan M. Smith and H. Dudley Sinnett and Nicholas C P Cross and R C Coombes},
  journal={Journal of clinical oncology : official journal of the American Society of Clinical Oncology},
  year={1999},
  volume={17 3},
  pages={870-9}
}
PURPOSE Previous reports have indicated that reverse transcriptase polymerase chain reaction (RT-PCR) for cytokeratin 19 (CK-19) may be useful in the management of patients with breast cancer. However, the specificity of this technique is low, principally because of a high rate of false-positive results. To improve the specificity of this assay, we developed a quantitative RT-PCR methodology that enables an estimate to be made of the number of CK-19 transcripts in blood and bone marrow samples… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 65 extracted citations

Similar Papers

Loading similar papers…