Quantitative phosphoproteomic analysis of the STAT3/IL-6/HIF1alpha signaling network: an initial study in GSC11 glioblastoma stem cells.

@article{Nilsson2010QuantitativePA,
  title={Quantitative phosphoproteomic analysis of the STAT3/IL-6/HIF1alpha signaling network: an initial study in GSC11 glioblastoma stem cells.},
  author={Carol L. Nilsson and Roslyn Dillon and Arugadoss Devakumar and Stone D-H Shi and Michael A. Greig and John C. Rogers and Bryan Krastins and Michael Rosenblatt and Gregory Kilmer and Michael B. Major and Barbara J Kaboord and David S Sarracino and Taha Rezai and Amol Prakash and Mary J. Lopez and Yongjie Ji and Waldemar Priebe and Frederick F. Lang and Howard Colman and Charles A. Conrad},
  journal={Journal of proteome research},
  year={2010},
  volume={9 1},
  pages={430-43}
}
Initiation and maintenance of several cancers including glioblastoma (GBM) may be driven by a small subset of cells called cancer stem cells (CSCs). CSCs may provide a repository of cells in tumor cell populations that are refractory to chemotherapeutic agents developed for the treatment of tumors. STAT3 is a key transcription factor associated with regulation of multiple stem cell types. Recently, a novel autocrine loop (IL-6/STAT3/HIF1alpha) has been observed in multiple tumor types… CONTINUE READING
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