Quantitative phase imaging using actively stabilized phase-shifting low-coherence interferometry.

@article{Iwai2004QuantitativePI,
  title={Quantitative phase imaging using actively stabilized phase-shifting low-coherence interferometry.},
  author={Hidenao Iwai and Christopher Fang-Yen and Gabriel Popescu and Adam Wax and Kamran Badizadegan and Ramachandra R. Dasari and M. S. Feld},
  journal={Optics letters},
  year={2004},
  volume={29 20},
  pages={
          2399-401
        }
}
We describe a quantitative phase-imaging interferometer in which phase shifting and noise cancellation are performed by an active feedback loop using a reference laser. Depth gating via low-coherence light allows phase measurement from weakly reflecting biological samples. We demonstrate phase images from a test structure and living cells. 

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References

SHOWING 1-10 OF 18 REFERENCES
Optical low-coherence reflectometer for differential phase measurement.
TLDR
A birefringent-fiber-based dual-channel optical low-coherence reflectometer capable of differential phase measurement and results are presented that demonstrate the accuracy and sensitivity of the system.
Differential phase contrast in optical coherence tomography.
TLDR
A modification of optical coherence tomography (OCT) that allows one to measure small phase differences between beams traversing adjacent areas of a specimen and determine path-difference gradients with a resolution of the order of 5 x 10(-5) .
Adjustable phase control in stabilized interferometry.
We report an optoelectronic feedback loop that permits the active stabilization of an interferometric setup for any chosen value of the phase between the interfering beams. This method is based on
Thermal-light full-field optical coherence tomography.
TLDR
This system, based on a Linnik-type interference microscope, illuminated by a white-light thermal lamp, has the highest resolution demonstrated to date for OCT imaging and realistic volume rendering of structures inside biological tissues is possible.
Polarization-sensitive low-coherence reflectometer for birefringence characterization and ranging
We present a polarization-sensitive optical coherence-domain reflectometer capable of characterizing the phase retardation between orthogonal linear polarization modes at each reflection point in a
High-resolution full-field optical coherence tomography with a Linnik microscope.
TLDR
An original microscope for high-resolution optical coherence tomography applications based on a Linnik interference microscope with high-numerical-aperture objectives that allows tomography in scattering media such as biological tissues.
In vivo ultrahigh-resolution optical coherence tomography.
TLDR
To overcome depth-of-field limitations the authors perform zone focusing and image fusion to construct a tomogram with high transverse resolution throughout the image depth, which is to their knowledge the highest longitudinal resolution demonstrated to date for in vivo OCT imaging.
Phase-referenced interferometer with subwavelength and subhertz sensitivity applied to the study of cell membrane dynamics.
TLDR
A highly sensitive means of measuring cellular dynamics with a novel interferometer that can measure motional phase changes and transient volume changes of a few cells in a monolayer immersed in weakly hypotonic and hypertonic solutions is reported.
2pi ambiguity-free optical distance measurement with subnanometer precision with a novel phase-crossing low-coherence interferometer.
TLDR
A highly accurate phase-based technique for measuring arbitrarily long optical distance with subnanometer precision using a Michelson interferometer with a pair of harmonically related light sources, one cw and the other low coherence.
Simultaneous phase-shift interferometer
Interferometric testing of large optics over long path lengths has been hampered by vibration in the test set-up. The precision of phase measuring interferometry has not been able to provide
...
1
2
...