Quantitative performance metrics for robustness in circadian rhythms

  title={Quantitative performance metrics for robustness in circadian rhythms},
  author={Neda Bagheri and J{\"o}rg Stelling and Francis J. Doyle},
  volume={23 3},
MOTIVATION Sensitivity analysis provides key measures that aid in unraveling the design principles responsible for the robust performance of biological networks. Such metrics allow researchers to investigate comprehensively model performance, to develop more realistic models, and to design informative experiments. However, sensitivity analysis of oscillatory systems focuses on period and amplitude characteristics, while biologically relevant effects on phase are neglected. RESULTS Here, we… CONTINUE READING


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