Quantitative organ time activity curve extraction from rodent PET images without anatomical prior.

Abstract

PURPOSE Numerous new drug candidates fail because of inadequate pharmacokinetics. Positron emission tomography (PET) enables the noninvasive characterization of the drug in humans and animals. The aim of the present work was the comparison of methods for the extraction of organ time activity curves from rodent PET images without requiring resort to… (More)

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