Quantitative nanoproteomics for protein complexes (QNanoPX) related to estrogen transcriptional action.

@article{Cheng2010QuantitativeNF,
  title={Quantitative nanoproteomics for protein complexes (QNanoPX) related to estrogen transcriptional action.},
  author={Pai-Chiao Cheng and Hsiang-Kai Chang and Shu-Hui Chen},
  journal={Molecular & cellular proteomics : MCP},
  year={2010},
  volume={9 2},
  pages={209-24}
}
We developed an integrated proteomics approach using a chemically functionalized gold nanoparticle (AuNP) as a novel probe for affinity purification to analyze a large protein complex in vivo. We then applied this approach to globally map the transcriptional activation complex of the estrogen response element (ERE). This approach was designated as quantitative nanoproteomics for protein complexes (QNanoPX). In this approach, the positive AuNP-ERE probes were functionalized with polyethylene… CONTINUE READING

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