Quantitative muscle MRI to follow up late onset Pompe patients: a prospective study

@inproceedings{FigueroaBonaparte2018QuantitativeMM,
  title={Quantitative muscle MRI to follow up late onset Pompe patients: a prospective study},
  author={Sebasti{\'a}n Figueroa-Bonaparte and Jaume Llauger and Sonia Segovia and Izaskun Belmonte and Irene Pedrosa and Elena Montiel and Paula Montesinos and Javier Sanchez-Gonz{\'a}lez and A Alonso-Jim{\'e}nez and Eduard Gallardo and Isabel Illa and Jordi D{\'i}az-Manera},
  booktitle={Scientific Reports},
  year={2018}
}
Late onset Pompe disease (LOPD) is a slow, progressive disorder characterized by skeletal and respiratory muscle weakness. Enzyme replacement therapy (ERT) slows down the progression of muscle symptoms. Reliable biomarkers are needed to follow up ERT-treated and asymptomatic LOPD patients in clinical practice. In this study, 32 LOPD patients (22 symptomatic and 10 asymptomatic) underwent muscle MRI using 3-point Dixon and were evaluated at the time of the MRI with several motor function tests… CONTINUE READING
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