Quantitative morphology of the caudate and putamen in patients with cocaine dependence.

@article{Jacobsen2001QuantitativeMO,
  title={Quantitative morphology of the caudate and putamen in patients with cocaine dependence.},
  author={Leslie K. Jacobsen and Jay N. Giedd and Christopher H. Gottschalk and Thomas R. Kosten and John H. Krystal},
  journal={The American journal of psychiatry},
  year={2001},
  volume={158 3},
  pages={486-9}
}
OBJECTIVE Deficits in dopaminergic function may contribute to hypertrophy of striatal structures associated with typical neuroleptic treatment. In light of a body of research that has associated chronic cocaine use with extrapyramidal symptoms and striatal dopaminergic depletion, the authors looked for evidence of striatal dysmorphology in patients with chronic cocaine dependence. METHOD Caudate, putamen, and total brain volumes were quantified by means of magnetic resonance imaging in 25… CONTINUE READING

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