Quantitative morphology of the caudate and putamen in patients with cocaine dependence.

  title={Quantitative morphology of the caudate and putamen in patients with cocaine dependence.},
  author={Leslie K. Jacobsen and Jay N. Giedd and Christopher H. Gottschalk and Thomas R. Kosten and John H. Krystal},
  journal={The American journal of psychiatry},
  volume={158 3},
OBJECTIVE Deficits in dopaminergic function may contribute to hypertrophy of striatal structures associated with typical neuroleptic treatment. In light of a body of research that has associated chronic cocaine use with extrapyramidal symptoms and striatal dopaminergic depletion, the authors looked for evidence of striatal dysmorphology in patients with chronic cocaine dependence. METHOD Caudate, putamen, and total brain volumes were quantified by means of magnetic resonance imaging in 25… CONTINUE READING

From This Paper

Topics from this paper.


Publications citing this paper.
Showing 1-10 of 49 extracted citations

Gray matter abnormalities in cocaine versus methamphetamine-dependent patients: a neuroimaging meta-analysis.

The American journal of drug and alcohol abuse • 2015
View 4 Excerpts
Highly Influenced

Similar Papers

Loading similar papers…