Quantitative morphology of human glioblastoma multiforme microvessels: structural basis of blood-brain barrier defect

Abstract

Neoplastic invasion of the brain parenchyma results in a disruption of the ultrastructure of the blood vessel walls such that serum proteins extravasate into the surrounding tissue, resulting in cerebral edema. The structural changes involved are not well understood, since the pores through which serum constituents pass (permeability routes) in normal… (More)
DOI: 10.1007/BF00148386

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