Quantitative molecular magnetic resonance imaging of tumor angiogenesis using cNGR-labeled paramagnetic quantum dots.

@article{Oostendorp2008QuantitativeMM,
  title={Quantitative molecular magnetic resonance imaging of tumor angiogenesis using cNGR-labeled paramagnetic quantum dots.},
  author={Marlies Oostendorp and Kim Douma and Tilman M. Hackeng and Anouk Dirksen and Mark J. Post and Marc A. M. J. van Zandvoort and Walter H. Backes},
  journal={Cancer research},
  year={2008},
  volume={68 18},
  pages={7676-83}
}
The objective of this study was to develop and apply cyclic Asn-Gly-Arg (cNGR)-labeled paramagnetic quantum dots (cNGR-pQDs) for the noninvasive assessment of tumor angiogenic activity using quantitative in vivo molecular magnetic resonance imaging (MRI). cNGR was previously shown to colocalize with CD13, an aminopeptidase that is highly overexpressed on angiogenic tumor endothelium. Because angiogenesis is important for tumor growth and metastatization, its in vivo detection and quantification… CONTINUE READING

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