Quantitative molecular imaging of viral therapy for pancreatic cancer using an engineered measles virus expressing the sodium-iodide symporter reporter gene.

@article{Carlson2009QuantitativeMI,
  title={Quantitative molecular imaging of viral therapy for pancreatic cancer using an engineered measles virus expressing the sodium-iodide symporter reporter gene.},
  author={Stephanie K. Carlson and Kelly L. Classic and Elizabeth M. Hadac and David Dingli and Claire E. Bender and Bradley J. Kemp and Stephen Russell},
  journal={AJR. American journal of roentgenology},
  year={2009},
  volume={192 1},
  pages={
          279-87
        }
}
OBJECTIVE Our objectives were to, first, determine the oncolytic potential of an engineered measles virus expressing the sodium-iodide symporter gene (MV-NIS) for intratumoral (i.t.) therapy of pancreatic cancer and, second, evaluate NIS as a reporter gene for in vivo monitoring and quantitation of MV-NIS delivery, viral spread, and gene expression in this tumor model. MATERIALS AND METHODS Cultured human pancreatic cancer cells were infected with MV-NIS. Light microscopy, cell viability, and… CONTINUE READING
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