Quantitative method for the profiling of the endocannabinoid metabolome by LC-atmospheric pressure chemical ionization-MS.

@article{Williams2007QuantitativeMF,
  title={Quantitative method for the profiling of the endocannabinoid metabolome by LC-atmospheric pressure chemical ionization-MS.},
  author={John S Williams and Jodianne T Wood and Lakshmipathi Pandarinathan and David A. Karanian and Ben A Bahr and Paul Vouros and Alexandros Makriyannis},
  journal={Analytical chemistry},
  year={2007},
  volume={79 15},
  pages={5582-93}
}
The endocannabinoid system's biological significance continues to grow as novel endocannabinoid metabolites are discovered. Accordingly, a myopic view of the system that focuses solely on one or two endocannabinoids, such as anandamide or 2-arachidonoyl glycerol, is insufficient to describe the biological responses to perturbations of the system. Rather, the endocannabinoid metabolome as a whole must be analyzed. The work described here is based on liquid chromatography coupled with atmospheric… CONTINUE READING