Quantitative metabolic profiling of 21 endogenous corticosteroids in urine by liquid chromatography-triple quadrupole-mass spectrometry.

@article{Cho2009QuantitativeMP,
  title={Quantitative metabolic profiling of 21 endogenous corticosteroids in urine by liquid chromatography-triple quadrupole-mass spectrometry.},
  author={Hye-Jin Cho and Jong Dae Kim and Won-Yong Lee and Bong Chul Chung and Man Ho Choi},
  journal={Analytica chimica acta},
  year={2009},
  volume={632 1},
  pages={101-8}
}
Since corticosteroid metabolism may be affected by disease states, the accurate and precise measurement of endogenous corticosteroids in urine is necessary to understand their biochemical roles. An efficient quantitative profiling of 21 endogenous corticosteroids in urine has been validated by liquid chromatography-tandem mass spectrometry (LC-MS/MS). After enzymatic hydrolysis with beta-glucuronidase, samples were purified using a solid-phase extraction cartridge and then separated through a… CONTINUE READING

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