Quantitative metabolic fate of propranolol in the dog, rat, and hamster using radiotracer, high performance liquid chromatography, and gas chromatography-mass spectrometry techniques.

@article{Bargar1983QuantitativeMF,
  title={Quantitative metabolic fate of propranolol in the dog, rat, and hamster using radiotracer, high performance liquid chromatography, and gas chromatography-mass spectrometry techniques.},
  author={E M Bargar and U. Kristina Walle and Stephen A. Bai and Thomas Walle},
  journal={Drug metabolism and disposition: the biological fate of chemicals},
  year={1983},
  volume={11 3},
  pages={266-72}
}
The complete metabolic fate of propranolol has been difficult to assess because of its complexity. The aim of this study was therefore to develop an analytical approach that would permit separation and quantitation of all major propranolol metabolites. This was accomplished in the urine of dogs, rats, and hamsters using a combination of techniques. Propranolol, 25 mg/kg, was given together with [3H]propranolol po to dogs and ip to rats and hamsters. After hydrolysis with beta-glucuronidase and… CONTINUE READING

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