Quantitative mass spectrometry identifies drug targets in cancer stem cell-containing side population.

@article{Steiniger2008QuantitativeMS,
  title={Quantitative mass spectrometry identifies drug targets in cancer stem cell-containing side population.},
  author={Sebastian C. J. Steiniger and Judith A. Coppinger and Joerg Krueger and John Yates and Kim D Janda},
  journal={Stem cells},
  year={2008},
  volume={26 12},
  pages={3037-46}
}
A multifaceted approach is presented as a general strategy to identify new drug targets in a breast cancer stem cell-containing side population. The approach we have utilized combines side population cell sorting and stable isotope labeling by amino acids in cell culture with mass spectrometry to compare and identify proteins with differential expression profiles between side population cells, know to be enriched in cancer stem cells, and nonside population cells, which are depleted in cancer… CONTINUE READING

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