Quantitative mass spectral evidence for the absence of circulating brain natriuretic peptide (BNP-32) in severe human heart failure.

@article{Hawkridge2005QuantitativeMS,
  title={Quantitative mass spectral evidence for the absence of circulating brain natriuretic peptide (BNP-32) in severe human heart failure.},
  author={Adam M Hawkridge and Denise M. Heublein and H. R. Bergen and Alessandro Cataliotti and John C. Burnett and David C Muddiman},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2005},
  volume={102 48},
  pages={17442-7}
}
C-terminal brain (B-type) natriuretic peptide (BNP)-32 is a widely used clinical biomarker for the diagnosis, prognosis, and treatment of heart failure (HF). The 32-aa peptide is synthesized primarily in the atrial and ventricular myocardium and constitutes the mature biologically active form of immature BNP (pro-BNP). There has been mounting evidence that suggests BNP circulates in different structural forms that impact HF diagnosis and in vivo activity. Herein, we have developed and used an… CONTINUE READING