Quantitative magnetization transfer imaging of pre-lesional white-matter changes in multiple sclerosis.

@article{Fazekas2002QuantitativeMT,
  title={Quantitative magnetization transfer imaging of pre-lesional white-matter changes in multiple sclerosis.},
  author={Franz Fazekas and Stefan Ropele and Christian Enzinger and Thomas Seifert and Siegrid Strasser-Fuchs},
  journal={Multiple sclerosis},
  year={2002},
  volume={8 6},
  pages={479-84}
}
OBJECTIVE Previous magnetization transfer (MT) studies in multiple sclerosis (MS) suggest a reduction of the MT ratio (MTR) precedes new lesion development. To gain further insight into pre-lesional tissue abnormalities, we investigated the time course of additional quantitative MT parameters. METHODS Serial magnetic resonance imaging (MRI), including a gadolinium-enhanced T1 scan and MT imaging by means of a FastPACE sequence, was performed on 12 patients (4 males, 8 females) with relapsing… CONTINUE READING