Quantitative magnetization transfer imaging made easy with qMTLab: Software for data simulation, analysis, and visualization

  title={Quantitative magnetization transfer imaging made easy with qMTLab: Software for data simulation, analysis, and visualization},
  author={Jean-François Cabana and Ye Gu and Mathieu Boudreau and Ives R. Levesque and Yaaseen Atchia and John G. Sled and Sridar Narayanan and Douglas L. Arnold and G. Bruce Pike and Julien Cohen-Adad and Tanguy Duval and Manh-Tung Vuong and Nikola Stikov},
  journal={Concepts in Magnetic Resonance Part A},
Quantitative magnetization transfer imaging (qMTI) increases specificity to macromolecular content in tissue by modeling the exchange process between the liquid and the macromolecular pool. However, its use has been mostly restricted to researchers that have developed these methods, in part due to the need to write complicated in-house software for modeling and data analysis. We have developed a software package (qMTLab) with a simple and easy to use graphical user interface that unifies three… 
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Short repetition times in combination with high signal‐to‐noise ratios make bSSFP an ideal candidate for the acquisition of high resolution isotropic quantitative MT maps, as for the human brain, within clinically feasible acquisition times.
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The results of this study demonstrate that the approximations used in pulsed MT modeling are quite robust, and it was shown that the semisolid pool fraction, M0B, which is known to correlate strongly with myelin content, and the transverse relaxation time of macromolecular protons, T2B, could be evaluated with reasonable accuracy regardless of the model used.
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Fast macromolecular proton fraction mapping from a single off‐resonance magnetization transfer measurement
  • V. Yarnykh
  • Physics
    Magnetic resonance in medicine
  • 2012
It was demonstrated theoretically and experimentally that accuracy of the single‐point method depends on the offset frequency and flip angle of the saturation pulse, and optimal ranges of these parameters are 4–7 kHz and 600°–900°, respectively.