Quantitative lymphatic vessel trait analysis suggests Vcam1 as candidate modifier gene of inflammatory bowel disease

@article{Jurisic2010QuantitativeLV,
  title={Quantitative lymphatic vessel trait analysis suggests Vcam1 as candidate modifier gene of inflammatory bowel disease},
  author={Giorgia Jurisic and John P. Sundberg and Andr{\'e} Bleich and Edward H. Leiter and Karl W. Broman and Gwen Buechler and Lynn Alley and Dietmar Vestweber and Michael Detmar},
  journal={Genes and Immunity},
  year={2010},
  volume={11},
  pages={219-231}
}
Inflammatory bowel disease (IBD) is a chronic debilitating disease resulting from a complex interaction of multiple genetic factors with the environment. To identify modifier genes of IBD, we used an F2 intercross of IBD-resistant C57BL/6J-Il10−/− mice and IBD-susceptible C3H/HeJBir-Il10−/− (C3Bir-Il10−/−) mice. We found a prominent involvement of lymphatic vessels in IBD and applied a scoring system to quantify lymphatic vascular changes. Quantitative trait locus (QTL) analyses revealed a… CONTINUE READING

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