Quantitative light microscopic observations on Paneth cells of germ-free and ex-germ-free Wistar rats.

@article{Satoh1986QuantitativeLM,
  title={Quantitative light microscopic observations on Paneth cells of germ-free and ex-germ-free Wistar rats.},
  author={Yohichi Satoh and Katsushi Ishikawa and Kazuyuki Ono and Lutz Vollrath},
  journal={Digestion},
  year={1986},
  volume={34 2},
  pages={115-21}
}
Germ-free rats were inoculated with bacteria from feces of SPF rats, and the Paneth cells in the ileal crypts were observed at different time intervals after inoculation. 12 h after inoculation, the Paneth cells showed a striking degranulation and the occurrence of supranuclear vacuoles. The Paneth cell area was significantly reduced. Four days to 3 weeks after inoculation, the secretory granules of Paneth cells were abundant, and both number and area of Paneth cells showed a progressive… CONTINUE READING

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