Quantitative justification for target concentration intervention--parameter variability and predictive performance using population pharmacokinetic models for aminoglycosides.

@article{Matthews2004QuantitativeJF,
  title={Quantitative justification for target concentration intervention--parameter variability and predictive performance using population pharmacokinetic models for aminoglycosides.},
  author={Ivan Matthews and Carl M. J. Kirkpatrick and Nick H G Holford},
  journal={British journal of clinical pharmacology},
  year={2004},
  volume={58 1},
  pages={8-19}
}
AIMS [1] To quantify the random and predictable components of variability for aminoglycoside clearance and volume of distribution [2] To investigate models for predicting aminoglycoside clearance in patients with low serum creatinine concentrations [3] To evaluate the predictive performance of initial dosing strategies for achieving an aminoglycoside target concentration. METHODS Aminoglycoside demographic, dosing and concentration data were collected from 697 adult patients (> or =20 years… CONTINUE READING

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