Quantitative insulin sensitivity check index: a simple, accurate method for assessing insulin sensitivity in humans.

@article{Katz2000QuantitativeIS,
  title={Quantitative insulin sensitivity check index: a simple, accurate method for assessing insulin sensitivity in humans.},
  author={Abram Katz and S S Nambi and K. J. Mather and Alain D. Baron and Dean A. Follmann and Gail Sullivan and M. Quon},
  journal={The Journal of clinical endocrinology and metabolism},
  year={2000},
  volume={85 7},
  pages={
          2402-10
        }
}
  • A. KatzS. Nambi M. Quon
  • Published 1 July 2000
  • Medicine, Biology
  • The Journal of clinical endocrinology and metabolism
Insulin resistance plays an important role in the pathophysiology of diabetes and is associated with obesity and other cardiovascular risk factors. The "gold standard" glucose clamp and minimal model analysis are two established methods for determining insulin sensitivity in vivo, but neither is easily implemented in large studies. Thus, it is of interest to develop a simple, accurate method for assessing insulin sensitivity that is useful for clinical investigations. We performed both… 

Figures and Tables from this paper

Correlation between insulin suppression test and quantitative insulin sensitivity check index in hypertensive and normotensive obese patients.

The correlation among IST, QUICKI, and HOMA in a population of normotensive-obese and hypertensive-OBese patients is studied in order to determine their accuracy.

Is quantitative insulin sensitivity check index, a fair insulin sensitivity index in humans?

Obese diabetic and obese non-diabetic subjects were more insulin resistant than lean control subjects, the most insulin resistant being the obese diabetics whatever the insulin sensitive assessment test used.

The biochemical assessment of insulin resistance

The quantitative assessment of insulin sensitivity is not used for routine clinical purposes, but the emerging importance of insulin resistance has led to its wider application to research studies that have examined its pathogenesis, aetiology and consequences.

Diagnostic methods of insulin resistance in a pediatric population

Because the cut-off points to diagnose IR with values derived from ISI-Composite have not been established for pediatric populations, HOMA and QUICKI, despite their lack of precision, remain the most used in clinical practice.

Current approaches for assessing insulin sensitivity and resistance in vivo: advantages, limitations, and appropriate usage.

The merits, limitations, and appropriate use of current in vivo measures of insulin sensitivity/resistance, including the quantitative insulin sensitivity check index, are highlighted.

Transient and steady-state euglycemic clamp validation of a model for glycemic control and insulin sensitivity testing.

The model-based insulin sensitivity parameter, SI, highly correlates to ISIG in all subgroups, even when only considering a transient state, and offers the potential for a short, simple yet highly correlated, model- based assessment of insulin sensitivity that is not currently available.

Monte Carlo analysis of a new model-based method for insulin sensitivity testing

Limitations in the Use of Indices Using Glucose and Insulin Levels to Predict Insulin Sensitivity

Insulin sensitivity indices based on glucose and insulin levels should be used cautiously as measures of peripheral insulin sensitivity when comparing mixed gender and mixed race populations.

Comparison between surrogate indexes of insulin sensitivity and resistance and hyperinsulinemic euglycemic clamp estimates in mice.

This study compared glucose clamp-derived measures of insulin sensitivity (GIR and SI(Clamp)) with surrogate indexes, including quantitative insulin-sensitivity check index (QUICKI), homeostasis model assessment (HOMA), 1/HomA, log(HOMa), and 1/fasting insulin, using data from 87 mice with a wide range of insulin sensitivities to conclude that linear correlations of surrogate indexes with clamp data and predictive accuracy of surrogate Indexes in mice

Incorporation of the fasting plasma FFA concentration into QUICKI improves its association with insulin sensitivity in nonobese individuals.

It is suggested that the incorporation of fasting free fatty acid level into QUICKI is useful to improve its correlation with the clamp-based index of insulin sensitivity and its discriminatory power in case of mild insulin resistance.
...

References

SHOWING 1-10 OF 41 REFERENCES

Exploration of simple insulin sensitivity measures derived from frequently sampled intravenous glucose tolerance (FSIGT) tests. The Insulin Resistance Atherosclerosis Study.

The authors considered eight previously described measures or indices of indices of insulin sensitivity derived from the frequently sampled intravenous glucose tolerance test (FSIGT), and found that Galvin insulin sensitivity is simple to calculate, requires only a 50-minute FSIGT, and is significantly associated with SI(clamp) over a wide range of glucose tolerance.

A Simple Method for Quantitation of Insulin Sensitivity and Insulin Release from an Intravenous Glucose Tolerance Test

  • P. GalvinG. Ward F. Alford
  • Medicine, Biology
    Diabetic medicine : a journal of the British Diabetic Association
  • 1992
The shortened simple IVGTT method is practical, gives reliable simultaneous estimates of glucoseolerance, first phase insulin secretion and insulin sensitivity in a diverse group of individuals with normal to moderately impaired glucose tolerance, and therefore may be useful in population surveys where prolonged, multiple blood sampling test procedures are not possible.

The Homeostasis Model in the San Antonio Heart Study

HOMA provides a useful model to assess insulin resistance and β-cell function in epidemiological studies in which only fasting samples are available and that, further, it is critical to take into account the degree of insulin resistance in assessing insulin secretion by the HOMA model.

Estimates of in vivo insulin action in humans: comparison of the insulin clamp and the minimal model techniques.

There was only a weak correlation between estimates of insulin action assessed with the insulin clamp and the minimal model techniques, indicating that the insulin-independent component of total glucose disposal both varies widely among patients and contributes significantly to glucose uptake as assessed by the insulin clamped technique.

Direct comparison of standard and insulin modified protocols for minimal model estimation of insulin sensitivity in normal subjects.

Insulin infusion during FSIVGTT appears to improve the precision of minimal model estimation of S1 in normal subjects under experimental conditions.

A Comparison Between the Minimal Model and the Glucose Clamp in the Assessment of Insulin Sensitivity Across the Spectrum of Glucose Tolerance

The insulin-modified frequently sampled intravenous glucose tolerance test (FSIGTT) with minimal model analysis provides estimates of insulin sensitivity that correlate significantly with those from the glucose clamp, however, in NIDDM.

Equivalence of the insulin sensitivity index in man derived by the minimal model method and the euglycemic glucose clamp.

These methods are equivalent for assessment of overall insulin sensitivity in normal and insulin-resistant nondiabetic subjects.

Comparison of Estimates of Insulin Sensitivity From Minimal Model Analysis of the Insulin-Modified Frequently Sampled Intravenous Glucose Tolerance Test and the Isoglycemic Hyperinsulinemic Clamp in Subjects With NIDDM

Estimates of insulin sensitivity derived from minimal modeling of a 4-h insulin-modified FSIVGTT and the glucose clamp in subjects with non-insulin-dependent diabetes mellitus are compared.

The Insulin Sensitivity Index in Nondiabetic Man: Correlation Between Clamp-derived and IVGTT-derived Values

The correlation between S1 measures by clamp and IVGTT methods provides one step toward validation of the minimal model for studies of insulin action in man and in eight euglycemic women with a wider range of adiposity.

Non-Insulin-Mediated Glucose Disappearance in Subjects With IDDM: Discordance Between Experimental Results and Minimal Model Analysis

The minimal model appears to overestimate the effect of glucose per se on glucose uptake and underestimate the contribution of incremental insulin.