Quantitative in vivo receptor binding. I. Theory and application to the muscarinic cholinergic receptor.

@article{Frey1985QuantitativeIV,
  title={Quantitative in vivo receptor binding. I. Theory and application to the muscarinic cholinergic receptor.},
  author={Kirk A. Frey and Richard L. Ehrenkaufer and Serge L Beaucage and Bernard W. Agranoff},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={1985},
  volume={5 2},
  pages={421-8}
}
A novel approach to in vivo receptor binding experiments is presented which allows direct quantitation of binding site densities. The method is based on an equilibrium model of tracer uptake and is designed to produce a static distribution proportional to receptor density and to minimize possible confounding influences of regional blood flow, blood-brain barrier permeability, and nonspecific binding. This technique was applied to the measurement of regional muscarinic cholinergic receptor… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 10 extracted citations

Kinetic analysis of the metabotropic glutamate subtype 5 tracer [(18)F]FPEB in bolus and bolus-plus-constant-infusion studies in humans.

Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism • 2013

Comparison of bolus and infusion methods for receptor quantitation: application to [18F]cyclofoxy and positron emission tomography.

Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism • 1993

Kinetic analysis of 3-quinuclidinyl 4-[125I]iodobenzilate transport and specific binding to muscarinic acetylcholine receptor in rat brain in vivo: implications for human studies.

Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism • 1990

References

Publications referenced by this paper.
Showing 1-10 of 58 references

The character of the muscarinic receptors in different regions of the rat brain.

Proceedings of the Royal Society of London. Series B, Biological sciences • 1980
View 1 Excerpt
Highly Influenced

In situ injection

J. T. Coyle, M. E. Molliver, M. J. Kuhar
1978
View 2 Excerpts
Highly Influenced

Muscarinic cholinergic binding in rat brain.

Proceedings of the National Academy of Sciences of the United States of America • 1974
View 3 Excerpts
Highly Influenced

The characteristics of I-125 4. IQNB and H-3 QNB in uioo and in uitro

R. E. Gibson, D. J. Weckstein, +3 authors C W.
Eckelman • 1984
View 3 Excerpts

Similar Papers

Loading similar papers…