Quantitative in vitro to in vivo extrapolation of cell-based toxicity assay results

@article{Yoon2012QuantitativeIV,
  title={Quantitative in vitro to in vivo extrapolation of cell-based toxicity assay results},
  author={Miyoung Yoon and Jerry L. Campbell and Melvin E. Andersen and Harvey J. Clewell},
  journal={Critical Reviews in Toxicology},
  year={2012},
  volume={42},
  pages={633 - 652}
}
The field of toxicology is currently undergoing a global paradigm shift to use of in vitro approaches for assessing the risks of chemicals and drugs in a more mechanistic and high throughput manner than current approaches relying primarily on in vivo testing. However, reliance on in vitro data entails a number of new challenges associated with translating the in vitro results to corresponding in vivo exposures. Physiologically based pharmacokinetic (PBPK) modeling provides an effective… 
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